Part1. What is bacopa monnieri extract benefits?
Bacopa monniera extract is extracted and processed from the whole plant of Bacopa monniera, a plant of the genus Bacopa monniera in the family Scrophulariaceae, and mainly contains triterpenoid saponins. It has pharmacological activities such as improving memory, sedative, antiepileptic, anti-inflammatory, antipyretic and analgesic.
Part2. Pharmacological effects
1. Pharmacological activity on nerve
(1) Beneficial effects on learning and memory
Studies have shown that Bacopa monnieri and its extracts have brain-building effects. Bacopa monnieri and its ethanol extract can significantly improve learning ability, and the promotion of cognitive function is mainly due to the two active saponins of Bacopa monnieri saponin A and B in the ethanol extract. In addition to promoting normal learning and memory functions, the active ingredient can also inhibit amnesia (loss of memory) induced by scopolamine, electric shock and restraint stress.
(2) Anti-anxiety effect
Bacopa monnieri extract is different from benzodiazepine anxiolytics, the former can improve cognitive function while producing anxiolytic effect, while the latter has side effects of causing dementia. The anti-anxiety effect of high-dose Bacopa monnieri extract is stronger, obviously better than LZP. Bacopa monnieri not only does not cause dementia, but can enhance the memory function of demented animals and people.
(3) Antidepressant effect
Methanol standard extract of Bacopa monniera has a strong antidepressant effect on rodent depression model, compared with antidepressant imipramine (15mg/kg), in forced swimming and acquired helpless depression models given daily sham Purslane 20 or 40mg/kg once, continuous administration for 5 days, can produce obvious antidepressant effect.
(4) Anticonvulsant effect
Bacopa monnieri was used alone or in combination with phenytoin (an anticonvulsant drug that causes cognitive dysfunction). The passive avoidance test, the maximum number of electroshock seizures and motor function in mice were evaluated. The results showed that phenytoin can impair cognitive function. function, and Bacopa monnieri can reverse the impairment of phenytoin on cognitive function, significantly improve memory acquisition and memory retention, but does not affect the anticonvulsant effect of phenytoin; Bacopa monnieri used alone or in combination with other antiepileptic drugs also confirmed Bacopa monnieri has a strong antiepileptic effect, and can correct the damage of antiepileptic drugs to cognitive function.
2. Anti-tumor effect
Bacopa monnieri extract can inhibit the growth of tumor cells at low concentrations; the toxicity at high concentrations still needs further in vivo experiments to be clarified. The drug's mode of action may be by inhibiting DNA replication.
3. Liver protection
Studies have shown that Bacopa monniera prevents the inhibition of antioxidant enzymes and the reduction of glutathione levels, inhibits the increase of lipid peroxide after morphine administration, and thus has a hepatoprotective effect on morphine-induced liver poisoning in rats.
4. Relaxes smooth muscles
The relaxation effect induced by Pseudomonas may involve prostacyclin compounds and β-adrenergic receptors. In addition, this relaxation effect does not depend on the activation of endothelial and muscarinic receptors.
5. Other functions
In addition to psychoactive effects, anti-inflammatory, cardiotonic and other pharmacological effects of Bacopa monnieri preparations or extracts were also evaluated. The effect of Bacopa monnieri on inhibiting experimental inflammation was compared with that of the anti-inflammatory drug indomethacin, and the results showed that BM effectively inhibited experimental inflammatory response by inhibiting prostaglandin synthesis and partially stabilizing lysosomal membranes, And Bacopa monniera does not cause gastrointestinal irritation at anti-inflammatory doses. Bacopa monniera extract can heal different types of inflammation.
Part3. Clinical efficacy
Nature and flavor slightly sweet, light, cold. It has the effects of clearing away heat and cooling blood, detoxifying and reducing swelling. For dysentery, conjunctival congestion and swelling pain, erysipelas, hemorrhoid swelling and pain, external application controls elephantiasis.
